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Sanford Guide API

Clinicians know more about their patients than we do, which is why we don’t presume to present only one choice for the treatment of detected pathogens. Instead, Sanford Guide gives prescribers concise clinical guidelines that allow patient history, symptoms, allergies, resistance patterns, and other factors to be taken into consideration before selecting an antimicrobial regimen.


Using Sanford Guide facilitates antimicrobial stewardship and improves patient outcomes by giving prescribers several treatment options based on the clinical scenario, ensuring that patients receive the right drug, in the right dose, for the right duration, and never a drug that they don’t need.

What it Is

Sanford Guide:
  • Provides effective, efficient, and responsible guidance
  • Includes comprehensive yet concise information that is easy to follow even when time is short
  • Avoids oversimplification and maintains autonomy by providing options for treatment
  • Allows for consideration of patientspecific factors to prescribe based on the infection suspected and the organisms isolated
  • Is interactive, allowing prescribers to get more information with one click
  • Aligns with recommendations to improve antibiotic prescribing through use of nationally recognized guidelines
  • Is curated by a 9-member editorial board of infectious diseases experts
  • Has been trusted for over 50 years to guide prescribing of antimicrobial therapy

What's Included

Syndrome information

Clinical setting, primary and alternative regimens (often in consideration of resistance detected), and antimicrobial stewardship considerations

Additional information regarding treatment of special populations such as pregnancy


Pathogen information

Clinical setting, classification, antimicrobial spectrum, primary and alternative regimens, considerations for resistance, antimicrobial stewardship considerations, and other information to guide therapy selection


Drug information

Adult dose, pediatric dose, renal and hepatic dose adjustment, dose adjustments based on other factors, adverse effects, spectrum, comprehensive pharmacology information, and drug interactions

How it Works

Treatment recommendations for detected pathogens and pertinent syndromes are seamlessly presented within your Healthcare IT platform. Prescribers can then deep dive into comprehensive drug information and related topics without exiting the platform. Sanford Guide empowers clinicians with the resources needed to make decisions efficiently and with confidence, which in turn saves time, saves money, and improves patient outcomes.

Why it Matters

Recent reports have described increasing drug-resistant infections particularly in community settings. Additionally, antibiotic adverse effects result in over 145,000 emergency department visits per year for adults. Other complications include Clostridioides difficile infection with more than 12,000 deaths per year. Optimizing antibiotic use is a public health priority, and improving antibiotic prescribing is one way to slow antibiotic resistance.


Infectious diseases diagnostics are constantly evolving with increasing levels of complexity. Due to a lack of knowledge of the sensitivity, specificity, and predictive value of newer molecular tests, providers may not have the confidence to interpret the results. The identification of organisms at an increasingly specific species-level along with multiple positive results of unknown clinical significance can be confusing and may lead to inappropriate treatment and unnecessary testing.


The complications associated with inappropriate treatment include antibiotic resistance, adverse events, poor outcomes, and increased healthcare costs.