Sanford Guide ID Update features current developments in infectious diseases, curated by the Sanford Guide Editorial Board. Links marked with an asterisk (*) provide details to Web Edition subscribers, while all other links are universal. To sign up for ID updates to your inbox, register here.
SARS-CoV-2 / COVID-19
Sanford Guide SARS-CoV-2 / COVID-19 material is freely available to all for the course of the pandemic.
- CDC: Interim public health recommendations for fully vaccinated people here.
- Currently authorized vaccines. See COVID-19 Prevention for table summarizing use and data.
- COVID-19 vaccination in cancer patients: preliminary recommendations from NCCN here.
- Guidelines on COVID-19 diagnosis, serology, treatment and management, and infection prevention: IDSA and NIH.
- Living WHO guideline on drugs for COVID-19 (BMJ 2021;374:n1703).
- Living WHO guideline on drugs to prevent COVID-19 (BMJ 2021;372:n526). Available here.
- Living WHO guideline on prophylaxis against COVID-19 (BMJ 2021;373:n949). Available at PMC.
- Management of hospitalized adults with COVID-19: a European Respiratory Society living guideline (Eur Respir J 2021;57(4):2100048). Available at PMC.
First COVID-19 Vaccine Approval
- The Pfizer-BioNTech COVID-19 mRNA vaccine (Comirnaty (koe-mir’-na-tee)), for the prevention of COVID-19 disease in persons 16 years of age and older. The vaccine also continues to be available under EUA for individuals 12-15 years of age and for the administration of a third dose in certain immunocompromised persons. Vaccination schedule: 2 doses (0.3 mL each) administered intramuscularly, 3 weeks apart.
- 2021-22 recommendations of the Advisory Committee on Immunization Practices (ACIP) regarding the use of seasonal influenza vaccines in the United States (MMWR Recomm Rep 2021;70;1-28). Available here.
New or Updated Practice Guidelines
- European Crohn’s and Colitis Organization (ECCO) guidelines on the prevention, diagnosis, and management of infections in inflammatory bowel disease (J Crohns Colitis 2021;15:879). The last update was in 2014. Available here.
- Japanese clinical practice guidelines for management of sepsis and septic shock 2020 (J-SSCG 2020) (J Intensive Care 2021;9:53). These guidelines, revised from J-SSCG 2016 jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, were first released in September 2020 and published in February 2021. An English-language version of these guidelines was created based on the contents of the original Japanese-language version. Available here.
Drug Shortages (US)
- Antimicrobial drugs or vaccines in reduced supply or unavailable (as of September 2, 2021) due to increased demand, manufacturing delays, product discontinuation by a specific manufacturer, or unspecified reasons:
- New on the list since August 10, 2021: Dicloxacillin capsules, Tocilizumab injection
- Shortage recently resolved: Ceftazidime-avibactam injection, Cidofovir injection, Chloroquine tablets
- Antibacterial and antimycobacterial drugs in continued reduced supply:
- Aminoglycosides: Amikacin injection, Gentamicin injection, Neomycin tablets, Tobramycin injection
- Carbapenems: Meropenem injection
- Cephalosporins: Cefazolin injection, Cefepime injection, Cefotaxime injection (FDA is allowing temporary importation of product from SteriMax in Canada, in conjunction with Apollo Pharmaceuticals and its distributor FFF Enterprises. Click here for details), Cefotetan injection, Ceftazidime injection, Ceftolozane-tazobactam injection
- Clindamycin injection
- Ethambutol tablets
- Fluoroquinolones: Ciprofloxacin 0.3% ophthalmic solution, Gemifloxacin tablets
- Glycopeptides, glycolipopeptides, lipopeptides: Vancomycin injection
- Macrolides/azalides: Azithromycin ophthalmic solution 1% (unavailable)
- Methanamine hippurate tablets
- Nitrofurantoin oral suspension
- Penicillins: Ampicillin-sulbactam injection, Piperacillin-tazobactam injection
- Tetracyclines: None
- Topical (miscellaneous) antibacterials: Bacitracin ophthalmic ointment, Neomycin and Polymyxin B sulfates GU irrigant, Neomycin and Polymyxin B sulfates and Dexamethasone ophthalmic ointment, Sulfacetamide 10%/Prednisolone 0.2% ophthalmic ointment (unavailable), Sulfanilamide 15% vaginal cream (unavailable)
- Antifungal, antiparasitic, and antiviral drugs in continued reduced supply:
- Clotrimazole 10 mg oral troches
- Hydroxychloroquine tablets
- Vaccines in continued reduced supply:
- Hepatitis B vaccine recombinant
- Antimicrobial drugs recently discontinued:
- Mupirocin calcium 2% cream (Bactroban [GSK], in June 2020), Bacitracin injection (in February 2020), Interferon alfa-2b (Intron A, in October 2019), Mupirocin calcium 2% nasal ointment (Bactroban Nasal [GSK], in August 2019), Quinidine gluconate IV (in December 2017), Terbinafine granules (in May 2017), MenHibrix (in February 2017), Elvitegravir (Vitekta, in December 2016), Peginterferon alfa-2b (in February 2016; 50 mcg vials still available in limited quantities), Boceprevir (in December 2015), Permethrin 1% topical lotion (in September 2015).
- For more detailed information including estimated resupply dates, see https://www.ashp.org/Drug-Shortages/