Jun '22 Infectious Disease Update
Jun 14th 2022
Sanford Guide ID Update features current developments in infectious diseases, curated by the Sanford Guide Editorial Board. Links marked with an asterisk (*) provide details to Web Edition subscribers, while all other links are universal. To sign up for ID updates to your inbox, register here.
SARS-CoV-2 / COVID-19
Sanford Guide SARS-CoV-2 / COVID-19 material is freely available to all for the course of the pandemic.
- COVID-19 vaccination in cancer patients: preliminary recommendations from NCCN here.
- Currently authorized vaccines. See COVID-19 Prevention for table summarizing use and data.
- ESCMID COVID-19 living guidelines: drug treatment and clinical management (Clin Microbiol Infect 2021 Nov 22 [online ahead of print]). Available at PMC.
- Guidelines on COVID-19 diagnosis, serology, treatment and management, and infection prevention: IDSA and NIH.
- Living WHO guideline on drugs for COVID-19 (BMJ 2021;375:n2936).
- Living WHO guideline on drugs to prevent COVID-19 (BMJ 2021;372:n526). Available here.
- Living WHO guideline on prophylaxis against COVID-19 (BMJ 2021;373:n949). Available at PMC.
- Management of hospitalized adults with COVID-19: a European Respiratory Society living guideline (Eur Respir J 2021;57(4):2100048). Available at PMC.
New co-packaged treatments for H. pylori
- Vonoprazan/amoxicillin/clarithromycin (brand name Voquezna "Triple Pak") and vonoprazan/amoxicillin (brand name Voquezna "Dual Pak") for the treatment of H. pylori infection in adults. Vonoprazan is an oral potassium-competitive acid blocker, co-packaged with amoxicillin ± clarithromycin. The recommended oral dosage of the Triple Pak is vonoprazan 20 mg bid + amoxicillin 1000 mg bid + clarithromycin 500 bid, with or without food, for 14 days. The recommended oral dosage of the Dual Pak is vonoprazan 20 mg bid + amoxicillin 1000 mg tid, with or without food, for 14 days. Product launch is expected in the third quarter of 2022.
New Dosage Form of Tecovirimat
- Tecovirimat 200 mg injection (brand name Tpoxx) for the treatment of human smallpox disease caused by variola virus in adults and pediatric patients weighing at least 3 kg. Recommended dosage (for up to 14 days): weight 3 to <35 kg, give 6 mg/kg IV q12h; weight 35 to <120 kg, give 200 mg IV q12h; weight ≥120 kg, give 300 mg IV q12h. Doses should be infused over 6 hours.
Drug Shortages (US)
- Antimicrobial drugs or vaccines in reduced supply or unavailable (as of June 13, 2022) due to increased demand, manufacturing delays, product discontinuation by a specific manufacturer, or unspecified reasons:
- New on the list since May 7, 2022:
- Shortage recently resolved:
- Acyclovir injection, Amphotericin B injection, Ethambutol tablets
- Antibacterial and antimycobacterial drugs in continued reduced supply:
- Amikacin injection
- Gentamicin injection
- Gentamicin sulfate 3% ophthalmic ointment
- Neomycin tablets
- Tobramycin injection
- Meropenem injection
- Cefazolin injection
- Cefepime injection
- Cefixime capsules
- Cefotaxime injection (FDA is allowing temporary importation of product from SteriMax in Canada, in conjunction with Provepharm Life Solutions and its distributor Direct Success. Click here for details),
- Ceftazidime injection
- Cefuroxime injection
- Clindamycin injection
- Doxycycline oral suspension
- Ciprofloxacin 0.3% ophthalmic solution
- Gemifloxacin tablets
- Glycopeptides, glycolipopeptides, lipopeptides:
- Vancomycin injection
- Azithromycin ophthalmic solution 1% (unavailable)
- Metronidazole injection
- Nitrofurantoin oral suspension
- Ampicillin-sulbactam injection
- Dicloxacillin capsules
- Piperacillin-tazobactam injection
- Quinupristin-Dalfopristin injection
- Topical (miscellaneous) antibacterials:
- Bacitracin ophthalmic ointment
- Neomycin and Polymyxin B sulfates GU irrigant
- Sulfacetamide 10%/Prednisolone 0.2% ophthalmic ointment (unavailable)
- Sulfanilamide 15% vaginal cream (unavailable)
- Antifungal drugs in continued reduced supply:
- Clotrimazole 10 mg oral troches
- Antimycobacterial drugs in continued reduced supply:
- Rifampin capsules
- Rifampin injection
- Rifapentine tablets
- Antiviral drugs in continued reduced supply:
- Tocilizumab injection
- Vaccines in continued reduced supply:
- New on the list since May 7, 2022:
- Antimicrobial drugs recently discontinued:
- Mupirocin calcium 2% cream (Bactroban [GSK], June 2020)
- Bacitracin injection (February 2020)
- Interferon alfa-2b (Intron A, October 2019)
- Mupirocin calcium 2% nasal ointment (Bactroban Nasal [GSK], August 2019)
- For more detailed information including estimated resupply dates, see https://www.ashp.org/Drug-Shortages/