Jun '22 Infectious Disease Update

Jun 14th 2022

Sanford Guide ID Update features current developments in infectious diseases, curated by the Sanford Guide Editorial Board. Links marked with an asterisk (*) provide details to Web Edition subscribers, while all other links are universal. To sign up for ID updates to your inbox, register here.

June 2022


Sanford Guide SARS-CoV-2 / COVID-19 material is freely available to all for the course of the pandemic.

New co-packaged treatments for H. pylori

  • Vonoprazan/amoxicillin/clarithromycin (brand name Voquezna "Triple Pak") and vonoprazan/amoxicillin (brand name Voquezna "Dual Pak") for the treatment of H. pylori infection in adults. Vonoprazan is an oral potassium-competitive acid blocker, co-packaged with amoxicillin ± clarithromycin. The recommended oral dosage of the Triple Pak is vonoprazan 20 mg bid + amoxicillin 1000 mg bid + clarithromycin 500 bid, with or without food, for 14 days. The recommended oral dosage of the Dual Pak is vonoprazan 20 mg bid + amoxicillin 1000 mg tid, with or without food, for 14 days. Product launch is expected in the third quarter of 2022.

New Dosage Form of Tecovirimat

  • Tecovirimat 200 mg injection (brand name Tpoxx) for the treatment of human smallpox disease caused by variola virus in adults and pediatric patients weighing at least 3 kg. Recommended dosage (for up to 14 days): weight 3 to <35 kg, give 6 mg/kg IV q12h; weight 35 to <120 kg, give 200 mg IV q12h; weight ≥120 kg, give 300 mg IV q12h. Doses should be infused over 6 hours.

Drug Shortages (US)

  • Antimicrobial drugs or vaccines in reduced supply or unavailable (as of June 13, 2022) due to increased demand, manufacturing delays, product discontinuation by a specific manufacturer, or unspecified reasons:
    • New on the list since May 7, 2022:
      • None
    • Shortage recently resolved:
      • Acyclovir injection, Amphotericin B injection, Ethambutol tablets
    • Antibacterial and antimycobacterial drugs in continued reduced supply:
      • Aminoglycosides:
        • Amikacin injection
        • Gentamicin injection
        • Gentamicin sulfate 3% ophthalmic ointment
        • Neomycin tablets
        • Tobramycin injection
      • Carbapenems:
        • Meropenem injection
      • Cephalosporins:
        • Cefazolin injection
        • Cefepime injection
        • Cefixime capsules
        • Cefotaxime injection (FDA is allowing temporary importation of product from SteriMax in Canada, in conjunction with Provepharm Life Solutions and its distributor Direct Success. Click here for details),
        • Ceftazidime injection
        • Cefuroxime injection
      • Clindamycin injection
      • Doxycycline oral suspension
      • Fluoroquinolones:
        • Ciprofloxacin 0.3% ophthalmic solution
        • Gemifloxacin tablets
      • Glycopeptides, glycolipopeptides, lipopeptides:
        • Vancomycin injection
      • Macrolides/azalides:
        • Azithromycin ophthalmic solution 1% (unavailable)
      • Metronidazole injection
      • Nitrofurantoin oral suspension
      • Penicillins:
        • Ampicillin-sulbactam injection
        • Dicloxacillin capsules
        • Piperacillin-tazobactam injection
      • Quinupristin-Dalfopristin injection
      • Topical (miscellaneous) antibacterials:
        • Bacitracin ophthalmic ointment
        • Neomycin and Polymyxin B sulfates GU irrigant
        • Sulfacetamide 10%/Prednisolone 0.2% ophthalmic ointment (unavailable)
        • Sulfanilamide 15% vaginal cream (unavailable)
    • Antifungal drugs in continued reduced supply
      • Clotrimazole 10 mg oral troches
    • Antimycobacterial drugs in continued reduced supply
      • Rifampin capsules
      • Rifampin injection
      • Rifapentine tablets
    • Antiviral drugs in continued reduced supply
      • Tocilizumab injection
    • Vaccines in continued reduced supply:
      • None
  • Antimicrobial drugs recently discontinued: 
    • Mupirocin calcium 2% cream (Bactroban [GSK], June 2020)
    • Bacitracin injection (February 2020)
    • Interferon alfa-2b (Intron A, October 2019)
    • Mupirocin calcium 2% nasal ointment (Bactroban Nasal [GSK], August 2019)