February ID Update

Sanford Guide ID Update features current developments in infectious diseases, curated by the Sanford Guide Editorial Board. Links marked with an asterisk (*) provide details to Web Edition subscribers, while all other links are universal. If you received this message from a colleague, subscribe now.



  • WHO officially names the virus 2019-nCoV as SARS-CoV-2*. The disease caused by the virus is named COVID-19.
  • Rapid advice guideline for the diagnosis and treatment of 2019-nCoV pneumonia, prepared in accordance with the methodology and general rules of WHO Guideline Development and the WHO Rapid Advice Guidelines (Mil Med Res 2020;7:4). The guidelines are available on the journal website.

New or Updated Treatment Guidelines

  • Clinical practice guidelines for the prevention and management of viral hepatitis in inflammatory bowel disease, from the Korean Association for the Study of Intestinal Diseases (Intest Res 2020;18:18). The guidelines are available on the journal website.
  • S2k guidelines for the diagnosis and treatment of herpes zoster and postherpetic neuralgia (J Dtsch Dermatol Ges 2020;18:55). These guidelines were developed on behalf of the German Herpes Management Forum under the auspices of the Paul Ehrlich Society of Chemotherapy.
  • Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children, from the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies (Pediatr Crit Care Med 2020;21:e52). The guidelines are available on the journal website.
  • Clinical practice guidelines for the management of vascular graft and stent graft infections, from the European Society for Vascular Surgery (Eur J Vasc Endovasc Surg 2020 Jan 30 [Epub ahead of print]).

From CDC

  • At its October 2019 meeting, the Advisory Committee on Immunization Practices (ACIP) voted to approve the 2020 Recommended Child and Adolescent Immunization Schedule for Ages 18 Years or Younger, and the 2020 Recommended U.S. Adult Immunization Schedule for Persons Aged 19 Years and Older. Tables and accompanying notes can be found on the CDC website.
  • Guidelines for the treatment of latent tuberculosis infection, from the National Tuberculosis Controllers Association and CDC (MMWR Recomm Rep 2020;69(No. RR-1):1–11). The guidelines are available on the CDC website.

From FDA

  • The US FDA has requested that all current manufacturers of bacitracin for injection voluntarily withdraw their product from the market. Based on FDA’s review of currently available data, FDA believes that the potential problems associated with bacitracin for injection are sufficiently serious to remove the drug from the market. This requested voluntary withdrawal does not impact approved topical or ophthalmic drugs that contain bacitracin. More information can be found here.

Drug Shortages (US)

  • Antimicrobial drugs or vaccines in reduced supply or unavailable (as of February 8, 2020) due to increased demand, manufacturing delays, product discontinuation by a specific manufacturer, or unspecified reasons:
    • [New on the list since January 5]: Erythromycin 0.5% ophthalmic ointment
    • [Shortage recently resolved]: Doxycycline hyclate injection, Letermovir injection, Rabies immune globulin, Rabies vaccine
    • [Continue to be in reduced supply]
      • Aminoglycosides: Amikacin injection, Gentamicin ophthalmic ointment (unavailable), Tobramycin injection
      • Carbapenems: Meropenem injection
      • Cephalosporins: Cefazolin injection, Cefepime injection, Cefotaxime injection (FDA is allowing temporary importation of product from SteriMax in Canada, in conjunction with Apollo Pharmaceuticals and its distributor FFF Enterprises. Click here for details), Cefoxitin injection, Ceftazidime injection, Cefuroxime injection
      • Clindamycin injection
      • Fluoroquinolones: Ciprofloxacin 0.3% ophthalmic solution, Gemifloxacin tablets
      • Glycopeptides, glycolipopeptides, lipopeptides: Daptomycin injection, Vancomycin injection
      • Macrolides/azalides: Azithromycin injection, Azithromycin ophthalmic solution 1% (unavailable), Erythromycin lactobionate injection
      • Nitrofurantoin oral suspension
      • Nitroimidazoles: Metronidazole injection
      • Penicillins: Ampicillin/sulbactam injection, Piperacillin/tazobactam injection
      • Tetracyclines: None
      • Topical (miscellaneous) antibacterials: Bacitracin ophthalmic ointment (unavailable), Mupirocin calcium 2% cream, Mupirocin calcium 2% nasal ointment (unavailable), Neomycin and Polymyxin B sulfates GU irrigant, Sulfacetamide 10%/Prednisolone 0.2% ophthalmic ointment, Sulfanilamide 15% vaginal cream (unavailable)
      • Antifungal drugs: Clotrimazole 10 mg oral troches, Fluconazole injection, Griseofulvin oral tablets and suspension
      • Antiparasitic drugs: Pentamidine isethionate
      • Antiretroviral drugs: None
      • Antiviral drugs: Acyclovir injection, Cidofovir injection
      • Vaccines: Hepatitis B vaccine recombinant, Zoster vaccine recombinant (Shingrix), Yellow Fever vaccine (YF-VAX is unavailable, but Stamaril can be obtained through a limited number of clinics in the US. Click here).
  • Antimicrobial drugs newly discontinued: 
    • Recent discontinuations: Interferon alfa-2b (Intron A, in October 2019), Quinidine gluconate IV (in December 2017), Terbinafine granules (in May 2017), MenHibrix (in February 2017), Elvitegravir (Vitekta, in December 2016), Peginterferon alfa-2b (in February 2016; 50 mcg vials still available in limited quantities), Boceprevir (in December 2015), Permethrin 1% topical lotion (in September 2015).